Tobacco prohibition would never work. I'm not so much against banning smoking in public (I think businesses will start doing this long before government ever does), since it is actually a logic more similar to banning drunk driving than banning alcohol. Smoking in public has effects on people who share the air. People who don't smoke are becoming more conscious of this. The great part is that more and more businesses will begin to make rules against smoking in order to appease the more and more people who would rather not share in the cancerous habits of zombie addicts.
And I'm sure there will still be no end to the complaining from addicts when they can't smoke in 90% of resturaunts due to the forces of the market. After all smokers think they're entitled to unlimited breaks at work. I hope to see more non-smoking managers in the future to put them in their place.

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"It's never over... BOY!"
The Tall Man, Phantasm III