Well since our favorite soap opera is coming to a close, how will Queen Cersei’s reign end, or will it? My money is on the imp. I think the prophesy by Maggie the frog shown in a earlier season all guarantees her demise.
I'm debating between four options on Cersei, listed from least likely to most likely: 1) She stays on the Iron Throne. 2) Tyrion shoots her with the crossbow that he gets from his buddy Bron. 3) Arya, in Jaime's mask, kills her. 4) Jaime kills her, and becomes the Queen Slayer as well as the King Slayer.
She will disappear in a way that implies her demise....in a few years she will reappear in a new production.
All I know is that HBO will (must) grant us this one 'boon' - Cersei's demise... it would be most epic if Danerysis Targaryan (or) Jamie Lanister (brother/lover) dramatically ended her life as she was clutching to the rudiments of some antithetical "Objective" (w/ the obligatory red wine glass in hand)... Just imho...