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COVID-19 Research, Drug trials and Pathophysiology

Discussion in 'Public Health' started by Bowerbird, Apr 13, 2020.

Posts do not contain medical or professional advice. Seek reliable alternate sources to verify information you read in this forum.

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  1. Bowerbird

    Bowerbird Well-Known Member

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    The intent of this thread is to post validated peer reviewed research on COVID-19

    Please respect the efforts made by those doing similar research

    World Health Organisation repository
    https://www.who.int/emergencies/dis...lobal-research-on-novel-coronavirus-2019-ncov

    The WHO page also lists other sites such as

    Other resources on coronavirus disease (COVID-19)
    How to confine your searches to research papers

    https://scholar.google.com.au/

    Note google scholar also has a list of evidence based medicine sites

    CDC
    NEJM
    JAMA
    Lancet
    Cell
    BMJ
    Nature
    Science
    Elsevier
    Oxford
    Wiley
    medRxiv

    Looking forward to discussing the research on COVID-19 with those interested in basing their arguments in a scientific and academic framework
     
    Last edited: Apr 13, 2020
    Bowerbird, Apr 13, 2020
    #1
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  2. Bowerbird

    Bowerbird Well-Known Member

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    Bowerbird, Apr 13, 2020
    #2
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  3. Lesh

    Lesh Banned

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    You'll find no interest in this by Trumpers because Trump doesn't endorse it
     
    Lesh, Apr 13, 2020
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  4. Lesh

    Lesh Banned

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    Wow. I called that one
     
    Lesh, Apr 14, 2020
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  5. Bowerbird

    Bowerbird Well-Known Member

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    Yep! But I am building a repository of research basically to silence those who are claiming that thier blog posts are more valid than systematic review of literature

    https://search.bvsalud.org/global-research-on-novel-coronavirus-2019-ncov/resource/en/covidwho-42154
     
    Bowerbird, Apr 14, 2020
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  6. Bowerbird

    Bowerbird Well-Known Member

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    Bowerbird, Apr 14, 2020
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  7. Bowerbird

    Bowerbird Well-Known Member

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    So,,,,,,,”we know all about the side effects of HCQ?

    https://onlinelibrary.wiley.com/doi/abs/10.1111/dth.13380

    Famous last words
     
    Bowerbird, Apr 14, 2020
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  8. Bowerbird

    Bowerbird Well-Known Member

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    New information on the aetiology of respiratory failure in COVID 19

    https://link.springer.com/article/10.1007/s00134-020-06033-2
     
    Bowerbird, Apr 15, 2020
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  9. 557

    557 Well-Known Member

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    Don’t want to drink fish tank cleaner? Don’t like the green apple horse dewormer? Or just want something effective that you don’t have to wait for your favorite politician to endorse? Want to make sure the promised vaccine will work well for your? This may be for you!

    Exercise!

    As an introduction:
    https://www.google.com/amp/s/www.irishtimes.com/life-and-style/health-family/fitness/does-exercise-help-or-hinder-the-body-s-ability-to-fight-off-infections-1.4198614?mode=amp

    Of course everyone has heard exercise is good for your overall health, but what about prevention and survival rates of viral infections? How about better immunity from vaccination? The above article points out what we’ve believed for years. That regular exercise does help the immune system fight off infection. It also alludes to the suspicion the immune system was suppressed immediately following more strenuous exercise. Turns out it’s the opposite. Exercise increases immune response in the lungs for instance after exercising. Here is a review of numerous studies leading to that conclusion. It also presents the evidence for increased immune response to vaccination in active individuals. Of course the linked review can be used to access the underlying research if one is interested in any of it.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5911985/
    Best of all, most benefits from exercise are available to everyone. Young or old, thin or not so thin. All you have to do is exercise!

    Of particular interest to me was the effect of exercise after infection occurs. Chris Cuomo madd some comments in a video I say that made me interested to learn more about this. He kept saying don’t lay down and die. Be active. Fight the virus. I can’t find the video right off, maybe someone can supply it if they have it. It was really good in my opinion.

    Anyway here’s a sample of research in this area.

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812897/

    https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0002108

    https://www.eurekalert.org/pub_releases/2020-04/uovh-cem041520.php
    Obviously we don’t know much about exercise and C19 specifically, but that’s the case for everything at this point.

    If nothing else, regular exercise will help with any underlying conditions you have or may develop such as obesity, heart disease, etc. that increase mortality rates astronomically with C19.
     
    Last edited: Apr 15, 2020
    557, Apr 15, 2020
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  10. Bowerbird

    Bowerbird Well-Known Member

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    COVID-19 is showing a remarkable variation in presentation and pathophysiological response

     
    Bowerbird, Apr 16, 2020
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  11. Bowerbird

    Bowerbird Well-Known Member

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    Myocardial injury (heart disease)

    https://jamanetwork.com/journals/jamacardiology/article-abstract/2763845
     
    Bowerbird, Apr 16, 2020
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  12. Eleuthera

    Eleuthera Well-Known Member Donor

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    Eleuthera, Apr 16, 2020
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  13. Bowerbird

    Bowerbird Well-Known Member

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    More importantly that it is not misinterpreted by twonks on the Internet spreading misleading and dangerous information (Alex Jones et al)
     
    Bowerbird, Apr 16, 2020
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  14. Eleuthera

    Eleuthera Well-Known Member Donor

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    There will always be opposite opinions, some are respectable and some are not. Just let the truth prevail.
     
    Eleuthera, Apr 16, 2020
    #14
  15. Bowerbird

    Bowerbird Well-Known Member

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    Yes I agree

    Meanwhile we have people confusing anecdotal evidence with scientific research and that is frustrating
     
    Bowerbird, Apr 16, 2020
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  16. Bowerbird

    Bowerbird Well-Known Member

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    Small study from China on convalescent plasma

    https://jamanetwork.com/journals/jama/article-abstract/2763983
     
    Last edited: Apr 16, 2020
    Bowerbird, Apr 16, 2020
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  17. fiddlerdave

    fiddlerdave Well-Known Member Past Donor

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    I really like this description.

    This concept presents itself with a impressive conformity of non-uniformity!
     
    fiddlerdave, Apr 16, 2020
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  18. WillReadmore

    WillReadmore Well-Known Member

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    Brazil halted a hydroxychloroquine test due to heart damage according to an article in MedRxiv.

    Patients not getting the pacebo were given that drug plus azithromycin - which is often used in conjunction with hydroxychloroquine in the USA, too.

    The test was halted due to fatal heart arrhythmia showing up. Both those drugs are known to have heart risks.
     
    Last edited: Apr 16, 2020
    WillReadmore, Apr 16, 2020
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  19. MrTLegal

    MrTLegal Well-Known Member

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    Here is some good news on the treatment success from the drug Remdesivir

    Dow futures rally more than 800 points after Gilead coronavirus drug reportedly shows effectiveness

     
    MrTLegal, Apr 16, 2020
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  20. 557

    557 Well-Known Member

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    Ran across this today.
    https://www.thelancet.com/pdfs/journals/ebiom/PIIS2352-3964(20)30118-3.pdf
    Looks like a promising vaccine. Of particular interest to me was the micro needle array delivery system. No carriers, preservatives, or adjuvant. A patch with 100 microneedles made of cellulose deliver they vaccine to the skin. Very good and fast immune response as well as being a cheap delivery system that can be mass produced quickly. Also, the patch containing the dried vaccine can be irradiated to sterilize it to prevent contamination or infection of the recipient with an opportunistic pathogen.
     
    557, Apr 17, 2020
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  21. HereWeGoAgain

    HereWeGoAgain Banned

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    Alex Jones, Limbaugh, trump, and all of the shock anti-jocks.

    Covid 19 aka Republicans rediscover the reality of science.
     
    HereWeGoAgain, Apr 17, 2020
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  22. Lesh

    Lesh Banned

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    Lesh, Apr 17, 2020
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  23. 557

    557 Well-Known Member

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    557, Apr 17, 2020
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  24. Bowerbird

    Bowerbird Well-Known Member

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    Bowerbird, Apr 17, 2020
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  25. 557

    557 Well-Known Member

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    Read this shortly after it was posted and was struck by the section on development of resistance to remdesivir. Specifically how in past experimentation resistant viruses became less pathogenic and less robust even when they did infect.

    If this holds true for all similar viruses to the ones already known to have some response to remdesivir, it would be theoretically possible to artificially force populations of viral groups into being less pathogenic but more importantly less damaging even if infections occur. If we figure out the exact mechanism and could alter robustness without affecting ability to infect, it could be even better. It would take time and effort but could result in something similar to screwworm eradication. For those not familiar here’s a link.
    https://www.aphis.usda.gov/aphis/ou..._release_programs/screwworm/screwworm_history

    Of course an approach in virus would look very different because screwworm involves sexual reproduction, I’m just using screwworm as an example where coordinated efforts to alter populations can work.

    The wrench in the works of using remdesivir as described above would be the early reporting of 25% or more severe side effects including liver and kidney damage. The reporting on the latest trials (that we don’t have access to yet apparently) doesn’t mention side effects so that may or may not be accurate.

    Anyway, this is a fascinating drug whether it’s the final answer to C19 or not.
     
    557, Apr 17, 2020
    #25
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